Size and molecular properties of the acetylcholine-receptor protein of muscle [proceedings].

ligand because the smaller molecular forms, which would be better able to penetrate the agarose gel, are not bound, whereas the larger form does bind. The gel can also discriminate between acetylcholinesterase and cholinesterase. This is unexpected because edrophonium is a competitive inhibitor of both enzymes. This suggests that the coupling of a side chain to the meta-hydroxy group of edrophonium alters the inhibitory properties of the molecule.